Cancer cell, 2006-04, Vol.9 (4), p.287-300
2006
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- Autor(en) / Beteiligte
- Titel
- Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain
- Ist Teil von
- Cancer cell, 2006-04, Vol.9 (4), p.287-300
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Stem cell factor (SCF) is overexpressed by neurons following brain injury as well as by glioma cells; however, its role in gliomagenesis remains unclear. Here, we demonstrate that SCF directly activates brain microvascular endothelial cells (ECs) in vitro and induces a potent angiogenic response in vivo. Primary human gliomas express SCF in a grade-dependent manner and induce normal neurons to express SCF in brain regions infiltrated by glioma cells, areas that colocalize with prominent angiogenesis. Downregulation of SCF inhibits tumor-mediated angiogenesis and glioma growth in vivo, whereas overexpression of SCF is associated with shorter survival in patients with malignant gliomas. Thus, the SCF/c-Kit pathway plays an important role in tumor- and normal host cell-induced angiogenesis within the brain.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1535-6108eISSN: 1878-3686DOI: 10.1016/j.ccr.2006.03.003Titel-ID: cdi_proquest_miscellaneous_67866550
- Format
- –
- Schlagworte
- Animals, Brain - blood supply, Brain - drug effects, Brain - metabolism, CELLCYCLE, Cells, Cultured, Down-Regulation, Endothelial Cells - drug effects, Endothelial Cells - metabolism, Fibroblast Growth Factors - genetics, Fibroblast Growth Factors - metabolism, Fibroblast Growth Factors - pharmacology, Gene Expression Regulation, Neoplastic, Glioma - blood supply, Glioma - genetics, Glioma - metabolism, Glioma - pathology, Humans, Mice, Neurons - metabolism, Protein Binding, Proto-Oncogene Proteins c-kit - metabolism, RNA, Small Interfering - genetics, Signal Transduction, Stem Cell Factor - genetics, Stem Cell Factor - metabolism, Stem Cell Factor - pharmacology, Survival Rate