Details

Autor(en) / Beteiligte

• Kohut, M.L.
• McCann, D.A.
• Russell, D.W.
• Konopka, D.N.
• Cunnick, J.E.
• Franke, W.D.
• Castillo, M.C.
• Reighard, A.E.
• Vanderah, E.

Titel

Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of β-blockers, BMI, and psychosocial factors in older adults

Ist Teil von

• Brain, behavior, and immunity, 2006-05, Vol.20 (3), p.201-209

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• Increased serum levels of inflammatory mediators have been associated with numerous disease states including atherosclerosis, Type II diabetes, hypertension, depression, and overall mortality. We hypothesized that a long-term exercise intervention among older adults would reduce serum inflammatory cytokines, and this reduction would be mediated, in part, by improvements in psychosocial factors and/or by β-adrenergic receptor mechanisms. Adults ⩾age 64 were randomly assigned to either an aerobic exercise treatment (CARDIO) or a flexibility/strength exercise treatment (FLEX) 3 days/week, 45 min/day for 10 months. A subgroup of subjects treated with non-selective β 1β 2 adrenergic antagonists were included to evaluate the potential role of β-adrenergic receptor adaptations as mediators of an exercise-induced change in inflammation. The inflammatory mediators [C-reactive protein (CRP), IL-6, tumor necrosis factor (TNF)-α, and IL-18] and the psychosocial factors (depression, perceived stress, optimism, sense of coherence, and social support) were measured pre- and post-intervention. The CARDIO treatment resulted in significant reductions in serum CRP, IL-6, and IL-18 compared to the FLEX treatment (significant treatment × time interaction, p < .05), whereas TNFα declined in both groups (main effect of time, p = .001). However, several psychosocial factors (depression, optimism, and sense of coherence) improved in both groups suggesting that the reduction of CRP, IL-6, and IL-18 in the CARDIO group was not mediated by improvements in psychosocial scores. With respect to the potential role of β-adrenergic receptors, both CARDIO subjects treated with β-adrenergic antagonists and those who were not treated with those medications demonstrated similar reductions in serum CRP, IL-6, IL-18, and TNFα. In summary, we have observed that an aerobic exercise intervention can significantly reduce serum inflammatory mediators, but β-adrenergic receptors and psychosocial factors do not appear to be involved.