Angewandte Chemie International Edition, 2006-04, Vol.45 (16), p.2585-2588
2006
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Details
- Autor(en) / Beteiligte
- Titel
- Glycosylation of a Neoglycoprotein by Using Glycosynthase and Thioglycoligase Approaches: The Generation of a Thioglycoprotein
- Ist Teil von
- Angewandte Chemie International Edition, 2006-04, Vol.45 (16), p.2585-2588
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Remodeling: Glycosylation of a neoglycoprotein was achieved in quantitative yields by using a glycosynthase or a thioglycoligase. The resulting glycoproteins function as good acceptors for glycosyl transferases, and the thioglycoprotein proved to be resistant to glycosidase digestion. The established technology will enable the remodeling of natural glycoproteins to make them more stable against degradation in serum.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1433-7851eISSN: 1521-3773DOI: 10.1002/anie.200503900Titel-ID: cdi_proquest_miscellaneous_67846017
- Format
- –
- Schlagworte
- Carbohydrate Sequence, enzyme models, glycoproteins, Glycoproteins - chemistry, Glycoproteins - metabolism, Glycosylation, Glycosyltransferases - chemistry, Glycosyltransferases - metabolism, Ligases - metabolism, Models, Molecular, Protein Structure, Tertiary, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Sulfhydryl Compounds - chemistry, thioglycoligases, thioglycoproteins