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Cyclin D3 expression in primary Ta/T1 bladder cancer
The Journal of pathology, 2006-05, Vol.209 (1), p.106-113
Lopez-Beltran, A
Requena, MJ
Luque, RJ
Alvarez-Kindelan, J
Quintero, A
Blanca, AM
Rodriguez, ME
Siendones, E
Montironi, R
2006
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Lopez-Beltran, A
Requena, MJ
Luque, RJ
Alvarez-Kindelan, J
Quintero, A
Blanca, AM
Rodriguez, ME
Siendones, E
Montironi, R
Titel
Cyclin D3 expression in primary Ta/T1 bladder cancer
Ist Teil von
The Journal of pathology, 2006-05, Vol.209 (1), p.106-113
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2006
Quelle
MEDLINE
Beschreibungen/Notizen
Cyclin D3 deregulation has recently been reported in bladder cancer but its prognostic significance remains uncertain. A cohort of 159 patients with stage Ta or T1 primary bladder tumours was investigated to determine the significance of cyclin D3 expression in association with other G1‐S phase regulators of the cell cycle (p53, p21Waf1, p27kip1, cyclin D1), including tumour proliferation (ki67‐MIB1); its association with conventional clinicopathological parameters; and the relationship between cyclin D3 and loss of heterozygosity (LOH) at the 9p21 (p16INK4a locus) chromosome region. The end point of the study was progression‐free survival. Cyclin D3, other G1‐S phase regulators, and tumour proliferation were investigated by immunohistochemistry and measured by the grid‐counting method. To validate the immunohistochemical expression, cyclin D3 was additionally assessed by western blotting in selected cases. LOH at the 9p21 chromosome region (marker D9S171) was assessed in 125 cases using an AB Prism 310 genetic analyser and a set of microsatellite fluorescence‐labelled primers. Cyclin D3 overexpression was related to larger tumour size (>5 cm; p < 0.0001) and high tumour proliferation (>10%; p = 0.025). Mean cyclin D3 expression increased with 2004 WHO grading categories in stage Ta (p = 0.035, ANOVA) and stage T1 (p = 0.047, t test) tumours. Cyclin D3 was not related to other clinicopathological parameters, G1‐S phase modulators, or 9p21 LOH. Cox's multivariate analysis selected cyclin D3 as an independent predictor of progression‐free survival (p = 0.0012, relative risk (RR) = 5.2366) together with tumour size (p = 0.0115, RR = 4.4442) and cyclin D1 (p = 0.0065, RR = 3.3023). Cyclin D3 expression had the highest risk ratio. Our results suggest that expression of cyclin D3 is relevant to the progression‐free survival of patients with Ta/T1 bladder carcinomas. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0022-3417
eISSN: 1096-9896
DOI: 10.1002/path.1952
Titel-ID: cdi_proquest_miscellaneous_67844327
Format
–
Schlagworte
9p21 loss of heterozygosity
,
Adult
,
Aged
,
Aged, 80 and over
,
Biomarkers, Tumor - metabolism
,
bladder cancer
,
Blotting, Western
,
Cell Cycle
,
Cell Differentiation
,
Chromosomes, Human, Pair 9 - genetics
,
cyclin D1
,
Cyclin D3
,
Cyclins - metabolism
,
Disease-Free Survival
,
Female
,
Humans
,
Immunoenzyme Techniques
,
Loss of Heterozygosity
,
Male
,
Middle Aged
,
Neoplasm Proteins - metabolism
,
progression
,
Proportional Hazards Models
,
tumour size
,
Urinary Bladder Neoplasms - genetics
,
Urinary Bladder Neoplasms - metabolism
,
Urinary Bladder Neoplasms - pathology
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