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Pathology, research and practice, 2005-01, Vol.201 (2), p.101-107
Ort / Verlag
Germany: Elsevier GmbH
Erscheinungsjahr
2005
Quelle
MEDLINE
Beschreibungen/Notizen
One of the major characteristics of atherosclerosis is the migration of smooth muscle cells (SMC) from the tunica media to the intima, caused by alterations in the environment, e.g. mechanical, chemical, or immunologic injuries of the arterial walls. A group of molecules that may act as a main regulator of SMC phenotype switching is formed by the so-called HMGA1 high-mobility group proteins. One target gene of the HMGA1 protein, playing a major role in the development of atherosclerotic lesions, is
CD44. The expression of
CD44 is regulated by IL-1
β
, but binding of HMGA1 potentiates the transactivation of the
CD44 promoter.
In this study, the HMGA1 expression of human atherosclerotic plaque samples was examined. Compared to the non-active components, all major components of the well-developed atherosclerotic plaques showed strong positivity of the high-mobility group protein HMGA1 in their activated areas, e.g. neointimal SMCs, macrophages, newly built blood vessels.
This report is the first to describe HMGA1 as one of the first mediators in the development of human atherosclerotic plaques.