FEMS microbiology letters, 2005-05, Vol.246 (2), p.221-228
2005
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Details
- Autor(en) / Beteiligte
- Titel
- Induction of murine macrophage TNF-α synthesis by Mycobacterium avium is modulated through complement-dependent interaction via complement receptors 3 and 4 in relation to M. avium glycopeptidolipid
- Ist Teil von
- FEMS microbiology letters, 2005-05, Vol.246 (2), p.221-228
- Ort / Verlag
- Oxford, UK: Elsevier B.V
- Erscheinungsjahr
- 2005
- Quelle
- Wiley Online Library All Journals
- Beschreibungen/Notizen
- We studied whether complement receptor (CR) mediated Mycobacterium avium interaction modulated macrophage TNF-α expression. Compared to control conditions, infections performed with C3-depletion yielded significantly higher TNF-α levels. Blockage of the CR4 iC3b site yielded increases in TNF-α for all morphotypic variants of a virulent serovar-8 strain (smooth transparent (SmT), smooth opaque (SmO), serovar-specific glycopeptidolipid (ssGPL) deficient knockout mutant) whereas CR3 blockage increased TNF-α only for SmT and ssGPL-deficient strains. Thus, complement-mediated binding of M. avium to CR3 and CR4 was shown to modulate TNF-α expression. The differential activation of morphotypic and isogenic variants of a single strain provides an excellent model system to delineate signaling pathways.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0378-1097eISSN: 1574-6968DOI: 10.1016/j.femsle.2005.04.008Titel-ID: cdi_proquest_miscellaneous_67835955
- Format
- –
- Schlagworte
- Animals, Bacteriology, Biological and medical sciences, Cell Line, Complement, Complement C3 - metabolism, Complement C4 - metabolism, Complement component C3, Complement receptor, Complement receptors, Complement system, Depletion, Fundamental and applied biological sciences. Psychology, Genetics, Glycolipids - genetics, Glycolipids - metabolism, Glycopeptides - genetics, Glycopeptides - metabolism, GPL, Humans, Macrophage, Macrophages, Macrophages - immunology, Mice, Microbiology, Mycobacterium avium, Mycobacterium avium Complex - genetics, Mycobacterium avium Complex - immunology, Mycobacterium avium Complex - metabolism, Mycobacterium avium-intracellulare Infection - immunology, Mycobacterium avium-intracellulare Infection - microbiology, Pathogens, Receptors, Receptors, Complement - metabolism, Serum proteins, TNF-α, Tumor Necrosis Factor-alpha - biosynthesis, Tumor necrosis factor-α