Bioorganic & medicinal chemistry, 2005-06, Vol.13 (11), p.3681-3689
2005
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Details
- Autor(en) / Beteiligte
- Titel
- Search for the pharmacophore in prazosin for Transport-P
- Ist Teil von
- Bioorganic & medicinal chemistry, 2005-06, Vol.13 (11), p.3681-3689
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2005
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- [Display omitted] Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural features of prazosin, which appear to be involved in binding to the putative transporter. It is shown that the pyrimidinyl 4-amino group is critically important for binding but that the 6,7-dimethoxy and 2-furoyl groups are not essential.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0968-0896eISSN: 1464-3391DOI: 10.1016/j.bmc.2005.03.030Titel-ID: cdi_proquest_miscellaneous_67801582
- Format
- –
- Schlagworte
- Biological and medical sciences, Cell Line, Chromatography, High Pressure Liquid, Magnetic Resonance Spectroscopy, Mass Spectrometry, Medical sciences, Molecular Structure, Neuropharmacology, Peptidergic neurones, Pharmacology. Drug treatments, Prazosin, Prazosin - chemistry, Prazosin - metabolism, Prazosin - pharmacology, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease), Psychology. Psychoanalysis. Psychiatry, Psychopharmacology, Transport-P, V-ATPase-linked uptake, Vacuolar Proton-Translocating ATPases - antagonists & inhibitors, Vacuolar Proton-Translocating ATPases - metabolism