Science (American Association for the Advancement of Science), 2006-03, Vol.311 (5767), p.1576-1580
2006
Details
- Autor(en) / Beteiligte
- Titel
- Large-Scale Sequence Analysis of Avian Influenza Isolates
- Ist Teil von
- Science (American Association for the Advancement of Science), 2006-03, Vol.311 (5767), p.1576-1580
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2006
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1121586Titel-ID: cdi_proquest_miscellaneous_67759810
- Format
- –
- Schlagworte
- Amino acids, Animals, Avian flu, avian influenza, Avian influenza virus, Biological and medical sciences, Birds - virology, Computational Biology, Epidemiology, Fundamental and applied biological sciences. Psychology, Genes, Genes, Viral, Genetics, genome, Genome, Viral, Genomes, Genomics, Genotype & phenotype, Genotypes, Horses, Human viral diseases, Humans, Infectious diseases, Influenza A virus, Influenza A virus - chemistry, Influenza A virus - genetics, Influenza A virus - isolation & purification, Influenza A virus - pathogenicity, Influenza A Virus, H1N1 Subtype - genetics, Influenza A Virus, H2N2 Subtype - genetics, Influenza A Virus, H3N2 Subtype - genetics, Influenza A Virus, H3N8 Subtype - genetics, Influenza A Virus, H5N1 Subtype - chemistry, Influenza A Virus, H5N1 Subtype - genetics, Influenza A Virus, H5N1 Subtype - pathogenicity, Influenza A Virus, H5N2 Subtype - genetics, Influenza A Virus, H7N7 Subtype - genetics, Influenza A Virus, H9N2 Subtype - genetics, Influenza in Birds - virology, Influenza, Human - virology, isolation, Medical sciences, Microbiology, Molecular Sequence Data, Mutation, Neurons, nucleotide sequences, Pandemics, Phylogeny, poultry, Proteins, Reassortant Viruses - genetics, Research Article, RNA, Viral - genetics, Sequence Analysis, DNA, Signatures, strain differences, strains, Swine, Viral diseases, Viral diseases of the respiratory system and ent viral diseases, Viral Nonstructural Proteins - chemistry, Viral Nonstructural Proteins - genetics, Viral Proteins - chemistry, Viral Proteins - genetics, Virology, Virulence Factors - chemistry, Virulence Factors - genetics, Viruses, wild birds