Details

Autor(en) / Beteiligte

• Cleland, John G.F
• Daubert, Jean-Claude
• Erdmann, Erland
• Freemantle, Nick
• Gras, Daniel
• Kappenberger, Lukas
• Tavazzi, Luigi

Titel

The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure

Ist Teil von

• The New England journal of medicine, 2005-04, Vol.352 (15), p.1539-1549

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2005

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Cardiac resynchronization improves left ventricular function and functional status in patients who have left ventricular systolic dysfunction and interventricular dyssynchrony due to a conduction delay. In a randomized trial comparing medical therapy alone with medical therapy plus cardiac resynchronization, combined therapy was associated with a significant reduction in the risk of death from any cause. In a randomized trial comparing medical therapy alone with medical therapy plus cardiac resynchronization, combined therapy was associated with a significant reduction in the risk of death from any cause. Despite improvements in pharmacologic treatment, many patients with heart failure have severe and persistent symptoms, and their prognosis remains poor. 1 , 2 Such patients commonly have regions of delayed myocardial activation and contraction, leading to cardiac dyssynchrony. In a series of trials lasting up to six months, cardiac resynchronization decreased symptoms and improved exercise capacity, the quality of life, and ventricular function. 3 – 7 The Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) trial showed that cardiac-resynchronization therapy alone or combined with an implantable defibrillator reduced the composite end point of death from any cause or hospitalization during a . . .