Details

Autor(en) / Beteiligte

• Gibson, Catherine S.
• MacLennan, Alastair H.
• Goldwater, Paul N.
• Haan, Eric A.
• Priest, Kevin
• Dekker, Gustaaf A.

Titel

The association between inherited cytokine polymorphisms and cerebral palsy

Ist Teil von

• American journal of obstetrics and gynecology, 2006-03, Vol.194 (3), p.674.e1-674.e11

Ort / Verlag

Philadelphia, PA: Mosby, Inc

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• The purpose of this study was to investigate associations between inherited cytokine polymorphisms and cerebral palsy. This was a case-control study that used DNA from the newborn infant screening cards of 443 white infants with cerebral palsy and 883 white control infants to test for the following cytokine polymorphisms: tumor necrosis factor–alpha-308, mannose-binding lectin–221, and 3 polymorphisms in exon-1 of the mannose-binding lectin gene at codon-52, -54, and -57. At all gestational ages mannose-binding lectin codon-54 increased the risk of the development of diplegia (homozygous or heterozygous odds ratio, 1.55; 95% CI, 1.03-2.32). For babies who were born at term, the risk of the development of quadriplegia was associated with heterozygous tumor necrosis factor–α (odds ratio, 1.82; 95% CI, 1.04-3.15), and mannose-binding lectin codon-54 was associated with diplegia (homozygous or heterozygous odds ratio, 2.12; 95% CI, 1.10-4.05). The presence of any polymorphism in mannose-binding lectin exon–1 at term approximately doubled the risk of the development of diplegia (odds ratio, 1.94; 95% CI, 1.05-3.62). Homozygous or heterozygous tumor necrosis factor–α was associated with hemiplegia for babies who were born at <32 weeks of gestation (odds ratio, 2.38; 95% CI, 1.02-5.58). Overall, the presence of any cytokine polymorphism was associated with cerebral palsy (odds ratio, 1.37; 95% CI, 1.02-1.84). Carriage of polymorphisms in the tumor necrosis factor–α and mannose-binding lectin genes are associated with an increased risk of cerebral palsy.