Details

Autor(en) / Beteiligte

• Jouvin-Marche, Evelyne
• Attuil-Audenis, Valerie
• Aude-Garcia, Catherine
• Rachidi, Walid
• Zabel, Mark
• Podevin-Dimster, Valerie
• Siret, Carole
• Huber, Christoph
• Martinic, Marianne
• Riondel, Jacqueline
• Villiers, Christian L
• Favier, Alain
• Naquet, Philippe
• Cesbron, Jean-Yves
• Marche, Patrice N

Titel

Overexpression of Cellular Prion Protein Induces an Antioxidant Environment Altering T Cell Development in the Thymus

Ist Teil von

• Journal of Immunology, 2006-03, Vol.176 (6), p.3490-3497

Ort / Verlag

United States: Am Assoc Immnol

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Wiley HSS Collection

Beschreibungen/Notizen

• Cellular prion protein (PrP(C)) is an ubiquitously expressed glycoprotein whose roles are still widely discussed, particularly in the field of immunology. Using TgA20- and Tg33-transgenic mice overexpressing PrP(C), we investigated the consequences of this overexpression on T cell development. In both models, overexpression of PrP(C) induces strong alterations at different steps of T cell maturation. On TgA20 mice, we observed that these alterations are cell autonomous and lead to a decrease of alphabeta T cells and a concomitant increase of gammadelta T cell numbers. PrP(C) has been shown to bind and chelate copper and, interestingly, under a copper supplementation diet, TgA20 mice presented a partial restoration of the alphabeta T cell development, suggesting that PrP(C) overexpression, by chelating copper, generates an antioxidant context differentially impacting on alphabeta and gammadelta T cell lineage.