Details

Autor(en) / Beteiligte

• Lambert, Paul-Henri
• Liu, Margaret
• Siegrist, Claire-Anne

Titel

Can successful vaccines teach us how to induce efficient protective immune responses?

Ist Teil von

• Nature medicine, 2005-04, Vol.11 (4 Suppl), p.S54-S62

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• Some recently introduced vaccines that have excellent efficacy records have been developed without a clear understanding of their mechanism of protection. In fact, successful vaccines have often emerged out of empirical observations and have only rarely been the result of a rational use of the continuously increasing immunological knowledge available to scientists. However, a posteriori deciphering of the biological bases for the efficacy of successful vaccines should be an essential component of research efforts directed at the development of new vaccines for the most challenging infectious diseases.