The Journal of infectious diseases, 2005-05, Vol.191 (9), p.1427-1434
- Coplan, Paul M.
- Gupta, Swati B.
- Dubey, Sheri A.
- Pitisuttithum, Punnee
- Nikas, Alex
- Mbewe, Bernard
- Vardas, Efthyia
- Schechter, Mauro
- Kallas, Esper G.
- Freed, Dan C.
- Fu, Tong-Ming
- Mast, Christopher T.
- Puthavathana, Pilaipan
- Kublin, James
- Brown Collins, Kelly
- Chisi, John
- Pendame, Richard
- Thaler, Scott J.
- Gray, Glenda
- Mcintyre, James
- Straus, Walter L.
- Condra, Jon H.
- Mehrotra, Devan V.
- Guess, Harry A.
- Emini, Emilio A.
- Shiver, John W.
2005
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- Autor(en) / Beteiligte
- Coplan, Paul M.
- Gupta, Swati B.
- Dubey, Sheri A.
- Pitisuttithum, Punnee
- Nikas, Alex
- Mbewe, Bernard
- Vardas, Efthyia
- Schechter, Mauro
- Kallas, Esper G.
- Freed, Dan C.
- Fu, Tong-Ming
- Mast, Christopher T.
- Puthavathana, Pilaipan
- Kublin, James
- Brown Collins, Kelly
- Chisi, John
- Pendame, Richard
- Thaler, Scott J.
- Gray, Glenda
- Mcintyre, James
- Straus, Walter L.
- Condra, Jon H.
- Mehrotra, Devan V.
- Guess, Harry A.
- Emini, Emilio A.
- Shiver, John W.
- Titel
- Cross-Reactivity of Anti–HIV-1 T Cell Immune Responses among the Major HIV-1 Clades in HIV-1–Positive Individuals from 4 Continents
- Ist Teil von
- The Journal of infectious diseases, 2005-05, Vol.191 (9), p.1427-1434
- Ort / Verlag
- Chicago, IL: The University of Chicago Press
- Erscheinungsjahr
- 2005
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- BackgroundThe genetic diversity of human immunodeficiency virus type 1 (HIV-1) raises the question of whether vaccines that include a component to elicit antiviral T cell immunity based on a single viral genetic clade could provide cellular immune protection against divergent HIV-1 clades. Therefore, we quantified the cross-clade reactivity, among unvaccinated individuals, of anti–HIV-1 T cell responses to the infecting HIV-1 clade relative to other major circulating clades MethodsCellular immune responses to HIV-1 clades A, B, and C were compared by standardized interferon-γ enzyme-linked immunospot assays among 250 unvaccinated individuals, infected with diverse HIV-1 clades, from Brazil, Malawi, South Africa, Thailand, and the United States. Cross-clade reactivity was evaluated by use of the ratio of responses to heterologous versus homologous (infecting) clades of HIV-1 ResultsCellular immune responses were predominantly focused on viral Gag and Nef proteins. Cross-clade reactivity of cellular immune responses to HIV-1 clade A, B, and C proteins was substantial for Nef proteins (ratio, 0.97 [95% confidence interval, 0.89–1.05]) and lower for Gag proteins (ratio, 0.67 [95% confidence interval, 0.62–0.73]). The difference in cross-clade reactivity to Nef and Gag proteins was significant (P<.0001) ConclusionsCross-clade reactivity of cellular immune responses can be substantial but varies by viral protein
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-1899eISSN: 1537-6613DOI: 10.1086/428450Titel-ID: cdi_proquest_miscellaneous_67709063
- Format
- –
- Schlagworte
- Adult, AIDS, Antigens, Biological and medical sciences, Consensus Sequence, Cross Reactions, Female, Fundamental and applied biological sciences. Psychology, Gene Products, nef - chemistry, Gene Products, nef - genetics, Geography, HIV, HIV 1, HIV Seropositivity - immunology, HIV-1 - classification, HIV-1 - immunology, HIV/AIDS, Human immunodeficiency virus 1, Human viral diseases, Humans, Immunity, Cellular, Infections, Infectious diseases, Male, Medical sciences, Microbiology, Middle Aged, Miscellaneous, nef Gene Products, Human Immunodeficiency Virus, Ratios, Reactivity, T lymphocytes, T-Lymphocytes - immunology, Vaccination, Viral diseases, Viral diseases of the lymphoid tissue and the blood. Aids, Virology, Viruses