AIDS (London), 2006-01, Vol.20 (2), p.287-289
2006
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Details
- Autor(en) / Beteiligte
- Titel
- Role of HIV-1 minority populations on resistance mutational pattern evolution and susceptibility to protease inhibitors
- Ist Teil von
- AIDS (London), 2006-01, Vol.20 (2), p.287-289
- Ort / Verlag
- Hagerstown, MD: Lippincott Williams & Wilkins
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We investigated, in the protease and GAG cleavage sites, the role of minority populations on the evolution of resistance to a subsequent boosted protease inhibitor (PI) regimen after a first failure to nelfinavir. Two pathways were observed: the addition of mutations to a currently dominant genotype when minority variants are not shown, or the emergence of a minority variant as a dominant strain. These minor species, not detected by standard genotype, may influence PI susceptibility.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0269-9370eISSN: 1473-5571DOI: 10.1097/01.aids.0000202650.03279.69Titel-ID: cdi_proquest_miscellaneous_67706374
- Format
- –
- Schlagworte
- AIDS/HIV, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antiviral agents, Biological and medical sciences, Drug Resistance, Multiple, Viral - genetics, Evolution, Molecular, Gene Products, gag - genetics, Genotype, HIV Infections - drug therapy, HIV Infections - virology, HIV Protease - genetics, HIV Protease Inhibitors - therapeutic use, HIV-1 - classification, HIV-1 - drug effects, HIV-1 - genetics, Human immunodeficiency virus 1, Human viral diseases, Humans, Immunodeficiencies, Immunodeficiencies. Immunoglobulinopathies, Immunopathology, Infectious diseases, Medical sciences, Nelfinavir - therapeutic use, Pharmacology. Drug treatments, Treatment Failure, Viral diseases, Viral diseases of the lymphoid tissue and the blood. Aids