Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (8), p.1993-1996
2005
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Details
- Autor(en) / Beteiligte
- Titel
- 2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (8), p.1993-1996
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- [Display omitted] We report the discovery and optimization of substituted 2-piperazinecarboxamides as potent and selective agonists of the melanocortin subtype-4 receptor. The 5- and 6-alkylated piperazine compounds exhibit low bioactivation potential as measured by covalent binding in microsome preparations.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2005.02.068Titel-ID: cdi_proquest_miscellaneous_67702705
- Format
- –
- Schlagworte
- Biological and medical sciences, Humans, Medical sciences, Melanocortin, Neuropharmacology, Neurotransmitters. Neurotransmission. Receptors, Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems, Pharmacology. Drug treatments, Piperazinecarboxamide, Piperazines - chemistry, Piperazines - metabolism, Piperazines - pharmacology, Receptor, Melanocortin, Type 4 - agonists, Receptor, Melanocortin, Type 4 - metabolism, Structure-Activity Relationship