Details

Autor(en) / Beteiligte

• Araújo, Fernando
• Antelmi, Ivana
• Pereira, Alexandre C.
• Latorre, Maria do Rosário D.O.
• Grupi, Cesar José
• Krieger, José E.
• Mansur, Alfredo José

Titel

Lower heart rate variability is associated with higher serum high-sensitivity C-reactive protein concentration in healthy individuals aged 46 years or more

Ist Teil von

• International journal of cardiology, 2006-03, Vol.107 (3), p.333-337

Ort / Verlag

Shannon: Elsevier Ireland Ltd

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• To test the hypothesis of an association between cardiac autonomic activity evaluated by heart rate variability and systemic inflammatory markers such as C-reactive protein, we studied the correlation of the indices of heart rate variability relative to serum high-sensitivity C-reactive protein (hs-CRP) in a healthy Brazilian population. Four hundred twenty-one healthy individuals aged 15–82 years (mean 40.4 years), 184 men (43.7%) and 237 women (56.3%) were enrolled between July 1998 and July 2001. The relationship between the log-transformed indices of the heart rate variability and the serum concentration of hs-CRP were analyzed stratified by age tertile using the Spearman correlation coefficient and multiple linear regression. The log standard deviation of all normal sinus RR intervals over 24 h (SDNN) ( r = − 0.801; p = 0.024) was independently correlated with log hs-CRP in the individuals with age in the oldest tertile (≥ 46 years). In addition, the body mass index (BMI) was independently correlated with hs-CRP in all of the age groups. In the healthy subjects aged 46 years or more the lower heart rate variability correlated with higher concentration of hs-CRP.