Details

Autor(en) / Beteiligte

• Lee, Sang Eok, MD
• Ryu, Keun Won, MD
• Nam, Byung Ho, PhD
• Lee, Jun Ho, MD
• Choi, Il Ju, MD
• Kook, Myeong-Cherl, MD
• Park, Sook Ryun, MD
• Kim, Young-Woo, MD

Titel

Prognostic Significance of Intraoperatively Estimated Surgical Stage in Curatively Resected Gastric Cancer Patients

Ist Teil von

• Journal of the American College of Surgeons, 2009-10, Vol.209 (4), p.461-467

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background The aim of this study was to assess the prognostic significance of intraoperatively estimated surgical stage (sStage) as a complementary role for pathologic stage (pStage) in gastric cancer. Study Design This was a retrospective study of 1,543 patients who underwent curative resection for gastric cancer. Clinicopathologic and therapeutic factors, including sStage, were analyzed for prognostic significance. Prognosis was stratified by sStage and pStage, and the prognoses of patients with an overestimated sStage were compared with those with a nonoverestimated sStage in the same pStage. Results Overall accuracy of sStage versus pStage was 39% (T stage, 73.0%; N stage, 43.5%). Survival curves were obviously stratified by sStage and pStage: Ia (97.5% versus 97.9%), Ib (94.3% versus 92.4%), II (89.6% versus 84.2%), IIIa (74.2% versus 69.3%), IIIb (54.4% versus 50.4%), and IV (55.6% versus 36.7%), respectively (p < 0.001). In addition to pStage, age and sStage were found to be significantly associated with overall survival by univariate and multivariate analysis. In pStages II, IIIa, and IIIb, intraoperatively overestimated patients had significantly poorer survival than nonoverestimated patients. Conclusions sStage should be considered as a complementary prognostic factor for pStage in gastric cancer after curative resection, especially in stages II and III patients.