Details

Autor(en) / Beteiligte

• Easton, Douglas F
• Al Olama, Ali Amin
• Kote-Jarai, Zsofia
• Giles, Graham G
• Guy, Michelle
• Morrison, Jonathan
• Severi, Gianluca
• Leongamornlert, Daniel A
• Tymrakiewicz, Malgorzata
• Jhavar, Sameer
• Saunders, Ed
• Hopper, John L
• Southey, Melissa C
• Muir, Kenneth R
• English, Dallas R
• Dearnaley, David P
• Ardern-Jones, Audrey T
• Hall, Amanda L
• O'Brien, Lynne T
• Wilkinson, Rosemary A
• Sawyer, Emma
• Lophatananon, Artitaya
• Horwich, Alan
• Huddart, Robert A
• Khoo, Vincent S
• Parker, Christopher C
• Woodhouse, Christopher J
• Thompson, Alan
• Christmas, Tim
• Ogden, Chris
• Cooper, Colin
• Donovan, Jenny L
• Hamdy, Freddie C
• Neal, David E
• Eeles, Rosalind A

Titel

Multiple loci on 8q24 associated with prostate cancer susceptibility

Ist Teil von

• Nature genetics, 2009-10, Vol.41 (10), p.1058-1060

Ort / Verlag

New York, NY: Nature Publishing Group

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 × 10−8; rs620861: OR = 0.90, P = 4.8 × 10−8). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.