Details

Autor(en) / Beteiligte

• Shalizi, Aryaman
• Gaudillière, Brice
• Yuan, Zengqiang
• Stegmůller, Judith
• Shirogane, Takahiro
• Ge, Qingyuan
• Tan, Yi
• Schulman, Brenda
• Harper, J. Wade
• Bonni, Azad

Titel

Calcium-Regulated MEF2 Sumoylation Switch Controls Postsynaptic Differentiation

Ist Teil von

• Science (American Association for the Advancement of Science), 2006-02, Vol.311 (5763), p.1012-1017

Ort / Verlag

Washington, DC: American Association for the Advancement of Science

Erscheinungsjahr

2006

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Postsynaptic differentiation of dendrites is an essential step in synapse formation. We report here a requirement for the transcription factor myocyte enhancer factor 2A (MEF2A) in the morphogenesis of postsynaptic granule neuron dendritic claws in the cerebellar cortex. A transcriptional repressor form of MEF2A that is sumoylated at lysine-403 promoted dendritic claw differentiation. Activity-dependent calcium signaling induced a calcineurin-mediated dephosphorylation of MEF2A at serine-408 and, thereby, promoted a switch from sumoylation to acetylation at lysine-403, which led to inhibition of dendritic claw differentiation. Our findings define a mechanism underlying postsynaptic differentiation that may modulate activity-dependent synapse development and plasticity in the brain.