Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Role of Positive Selection in the Retention of Duplicate Genes in Mammalian Genomes
Ist Teil von
Proceedings of the National Academy of Sciences - PNAS, 2006-02, Vol.103 (7), p.2232-2236
Ort / Verlag
United States: National Academy of Sciences
Erscheinungsjahr
2006
Quelle
MEDLINE
Beschreibungen/Notizen
The question of how duplicate genes are retained in a population remains controversial. The duplication-degeneration-complementation model, which involves no positive selection, stipulates a higher retention rate of duplicate genes in a small population than in a large one. This model has been accepted by many evolutionists. However, we found considerably more retentions and fewer losses of duplicate genes in the mouse genome than in the human genome, although the population size of rodents is in general larger than that of primates. Indeed, in nearly every interval of synonymous divergence between duplicate genes, the number of gene retentions in mouse is larger than that in human. Our findings suggest a more important role of positive selection in duplicate retention than duplication- degeneration- complementation. In addition, certain functional categories show a higher tendency of lineage-specific expansion than expected, suggesting lineagespecific selection or functional bias in retained duplicates.