FEBS letters, 2006-02, Vol.580 (5), p.1257-1262
2006
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Proteome analysis of rat liver mitochondria reveals a possible compensatory response to endotoxic shock
- Ist Teil von
- FEBS letters, 2006-02, Vol.580 (5), p.1257-1262
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 2006
- Quelle
- Wiley Online Library - AutoHoldings Journals
- Beschreibungen/Notizen
- Organ failure induced by endotoxic shock has recently been associated with affected mitochondrial function. In this study, effects of in vivo lipopolysaccharide-challenge on protein patterns of rat liver mitochondria in treated animals versus controls were studied by two-dimensional electrophoresis (differential image gel electrophoresis). Significant upregulation was found for ATP-synthase α chain and superoxide dismutase [Mn]. Our data suggest that endotoxic shock mediated changes in the mitochondrial proteome contribute to a compensatory reaction (adaptation to endotoxic shock) rather than to a mechanism of cell damage.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/j.febslet.2006.01.040Titel-ID: cdi_proquest_miscellaneous_67659094
- Format
- –
- Schlagworte
- 2-DE, 60 kD heat shock protein, alanine aminotransferase, ALDH1, ALT, Animals, ATP-synthase, Cell Respiration, differential image gel electrophoresis, DIGE, Electrophoresis, Gel, Two-Dimensional, Endotoxic shock, hsp60, Lipopolysaccharide, Lipopolysaccharides - pharmacology, LPS, mass spectrometry, Mitochondria, Mitochondria, Liver - chemistry, Mitochondria, Liver - metabolism, Mitochondria, Liver - pathology, mitochondrial aldehyde dehydrogenase, Oxygen - metabolism, Proteome - analysis, Proteomics, Rats, Rats, Sprague-Dawley, reactive oxygen species, Reactive Oxygen Species - metabolism, ROS, Shock, Septic - genetics, Shock, Septic - metabolism, SOD, Superoxide dismutase, two-dimensional electrophoresis