Cancer cell, 2006-02, Vol.9 (2), p.121-132
2006
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- X chromosomal abnormalities in basal-like human breast cancer
- Ist Teil von
- Cancer cell, 2006-02, Vol.9 (2), p.121-132
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1535-6108eISSN: 1878-3686DOI: 10.1016/j.ccr.2006.01.013Titel-ID: cdi_proquest_miscellaneous_67655627
- Format
- –
- Schlagworte
- Alleles, Biological Transport, Biomarkers, BRCA1 Protein - genetics, BRCA1 Protein - metabolism, Breast Neoplasms - genetics, Cell Nucleus - metabolism, Chromosome Aberrations, Chromosomes, Human, Pair 14 - genetics, Chromosomes, Human, Pair 17 - genetics, Chromosomes, Human, X - genetics, Cohort Studies, CpG Islands - genetics, DNA, DNA Methylation, Female, Gene Expression, Gene Silencing, Genes, X-Linked, Humans, Neoplasms, Basal Cell - genetics, RNA, Long Noncoding, RNA, Messenger - genetics, RNA, Untranslated - genetics, Uniparental Disomy