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Fertility preservation in young women with epithelial ovarian cancer
Cancer, 2009-09, Vol.115 (18), p.4118-4126
Wright, Jason D.
Shah, Monjri
Mathew, Leny
Burke, William M.
Culhane, Jennifer
Goldman, Noah
Schiff, Peter B.
Herzog, Thomas J.
2009
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Wright, Jason D.
Shah, Monjri
Mathew, Leny
Burke, William M.
Culhane, Jennifer
Goldman, Noah
Schiff, Peter B.
Herzog, Thomas J.
Titel
Fertility preservation in young women with epithelial ovarian cancer
Ist Teil von
Cancer, 2009-09, Vol.115 (18), p.4118-4126
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2009
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
BACKGROUND: Surgical management of ovarian cancer consists of hysterectomy with bilateral oophorectomy. In young women, this results in the loss of reproductive function and estrogen deprivation. In the current study, the authors examined the safety of fertility‐conserving surgery in premenopausal women with epithelial ovarian cancers. METHODS: Women aged ≤50 years with stage IA or IC epithelial ovarian cancer who were registered in the Surveillance, Epidemiology, and End Results database were examined. Patients who underwent bilateral oophorectomy were compared with those who underwent ovarian conservation. A second analysis examined uterine conservation versus hysterectomy. Multivariate Poisson regression models were developed to describe predictors of fertility preservation. Survival was examined using Cox proportional hazards models and the Kaplan‐Meier method. RESULTS: In total, 1186 women, including 754 women (64%) who underwent bilateral oophorectomy and 432 women (36%) who underwent ovarian preservation, were identified. Younger age, later year of diagnosis, and residence in the eastern or western United States were associated with ovarian preservation (P < .05 for all). Women with endometrioid and clear cell histologies and stage IC disease were less likely to have ovarian conservation (P < .05). In a Cox model, ovarian preservation had no effect on survival (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.39‐1.20). Young age, later year of diagnosis, residence in the eastern or western United States, single women, mucinous tumors, and patients with stage IA disease were more likely to have uterine preservation (P < .05 for all). In a multivariate model, uterine preservation had no effect on survival (HR, 0.87; 95% CI, 0.62‐1.22). CONCLUSIONS: Ovarian and uterine‐conserving surgery were safe in young women who had stage IA and IC epithelial ovarian cancer. Cancer 2009. © 2009 American Cancer Society. In this examination of the safety of fertility‐conserving surgery in premenopausal women with epithelial ovarian cancers, the results indicated that ovarian and uterine‐conserving surgery were safe in young women who had stage IA and IC ovarian cancer.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.24461
Titel-ID: cdi_proquest_miscellaneous_67649946
Format
–
Schlagworte
Adult
,
Biological and medical sciences
,
Female
,
Female genital diseases
,
Fertility
,
fertility‐conserving surgery
,
Gynecologic Surgical Procedures - methods
,
Gynecology. Andrology. Obstetrics
,
Humans
,
Hysterectomy
,
Medical sciences
,
Middle Aged
,
oophorectomy
,
ovarian cancer
,
Ovarian Neoplasms - mortality
,
Ovarian Neoplasms - surgery
,
Ovariectomy
,
SEER Program
,
Treatment Outcome
,
Tumors
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