Nature (London), 2009-09, Vol.461 (7261), p.230-235
2009
Details
- Autor(en) / Beteiligte
- Titel
- An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
- Ist Teil von
- Nature (London), 2009-09, Vol.461 (7261), p.230-235
- Ort / Verlag
- London: Nature Publishing Group
- Erscheinungsjahr
- 2009
- Link zum Volltext
- Quelle
- Psychology and Behavioral Sciences Collection
- Beschreibungen/Notizen
- Constitutive expression of telomerase in human cells prevents the onset of senescence and crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that the human telomerase reverse transcriptase catalytic subunit (TERT) contributes to cell physiology independently of its ability to elongate telomeres. Here we show that TERT interacts with the RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a gene that is mutated in the inherited pleiotropic syndrome cartilage-hair hypoplasia. Human TERT and RMRP form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer (also known as DICER1)-dependent manner. These observations identify a mammalian RdRP composed of TERT in complex with RMRP.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-0836eISSN: 1476-4687DOI: 10.1038/nature08283Titel-ID: cdi_proquest_miscellaneous_67644517
- Format
- –
- Schlagworte
- Biological and medical sciences, Cell Line, Diseases of the osteoarticular system, E coli, Endoribonucleases - genetics, Fundamental and applied biological sciences. Psychology, Gene expression, Gene Expression Regulation, HeLa Cells, Humans, Malformations and congenital and or hereditary diseases involving bones. Joint deformations, Medical sciences, Molecular and cellular biology, Molecular genetics, Protein Binding, Reverse transcriptase, Ribonuclease, Ribonuclease III - deficiency, Ribonuclease III - genetics, Ribonuclease III - metabolism, Ribonucleic acid, Ribonucleoproteins - genetics, Ribonucleoproteins - metabolism, RNA, RNA processing, RNA Replicase - chemistry, RNA Replicase - metabolism, RNA, Double-Stranded - biosynthesis, RNA, Double-Stranded - genetics, RNA, Double-Stranded - metabolism, RNA, Long Noncoding, RNA, Small Interfering - biosynthesis, RNA, Small Interfering - genetics, RNA, Small Interfering - metabolism, RNA, Untranslated - genetics, RNA, Untranslated - metabolism, Stem cells, Telomerase, Telomerase - genetics, Telomerase - metabolism, Transcription. Transcription factor. Splicing. Rna processing