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Role of prednisolone treatment in severe Mycoplasma pneumoniae pneumonia in children
Pediatric pulmonology, 2006-03, Vol.41 (3), p.263-268
Lee, Kyung-Yil
Lee, Hyung-Shin
Hong, Ja-Hyun
Lee, Mi-Hee
Lee, Joon-Sung
Burgner, David
Lee, Byung-Churl
2006
Details
Autor(en) / Beteiligte
Lee, Kyung-Yil
Lee, Hyung-Shin
Hong, Ja-Hyun
Lee, Mi-Hee
Lee, Joon-Sung
Burgner, David
Lee, Byung-Churl
Titel
Role of prednisolone treatment in severe Mycoplasma pneumoniae pneumonia in children
Ist Teil von
Pediatric pulmonology, 2006-03, Vol.41 (3), p.263-268
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2006
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Mycoplasma pneumoniae pneumonia (MP) is responsible for 10–40% of cases of pediatric community‐acquired pneumonia. Occasionally, progression to severe pneumonia occurs despite appropriate antibiotic therapy. We retrospectively evaluated the effect of prednisolone in 15 children with MP whose clinical and radiographic course worsened despite broad‐spectrum antibiotics, including appropriate macrolides. The mean ( ± SD) age was 6.1 ± 1.9 years, and 10 were boys. All children had received macrolides at presentation, but they had persistent fever and progressively worsening radiographic findings. In addition to broad‐spectrum antimicrobial therapy, we added prednisolone (1 mg/kg for 3–7 days, then tapered over 7 days) on day 6 (±1.5 days) of admission. Fourteen children became afebrile within 24 hr, and their clinical status and radiographic findings improved over several days. The white blood cell count at presentation was 7,500 ± 2,000/mm3, with a proportion demonstrating lymphopenia (lymphocyte differential, 19.7 ± 5.7%). In conclusion, corticosteroid treatment appeared to be temporally associated with clinical and radiographic improvement, and may be helpful for reducing morbidity in children with macrolide‐nonresponsive severe MP. Further studies may be warranted. Pediatr Pulmonol. © 2006 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 8755-6863
eISSN: 1099-0496
DOI: 10.1002/ppul.20374
Titel-ID: cdi_proquest_miscellaneous_67640561
Format
–
Schlagworte
Adolescent
,
Antibacterial agents
,
Antibiotics. Antiinfectious agents. Antiparasitic agents
,
Biological and medical sciences
,
Child
,
Child, Preschool
,
children
,
Dose-Response Relationship, Drug
,
Drug Administration Schedule
,
Drug Therapy, Combination
,
Female
,
Follow-Up Studies
,
Humans
,
macrolides
,
Macrolides - administration & dosage
,
Male
,
Medical sciences
,
Mycoplasma pneumoniae - drug effects
,
Mycoplasma pneumoniae - isolation & purification
,
Mycoplasma pneumoniae pneumonia
,
Pharmacology. Drug treatments
,
Pneumology
,
Pneumonia, Mycoplasma - diagnosis
,
Pneumonia, Mycoplasma - drug therapy
,
prednisolone
,
Prednisolone - administration & dosage
,
Radiography, Thoracic
,
Retrospective Studies
,
Risk Assessment
,
Severity of Illness Index
,
Treatment Outcome
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