Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1574-1578
2006
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1574-1578
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2005.12.051Titel-ID: cdi_proquest_miscellaneous_67636267
- Format
- –
- Schlagworte
- Binding Sites, Binding, Competitive, Biological and medical sciences, Crystallography, X-Ray, Diabetes, Enzyme Inhibitors - chemical synthesis, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, General and cellular metabolism. Vitamins, HTS screening, Humans, Ligands, Medical sciences, Models, Molecular, Molecular Mimicry, Pharmacology. Drug treatments, Phosphatase PTP1B, Phosphotyrosine - metabolism, Protein Binding, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Protein Tyrosine Phosphatases - antagonists & inhibitors, Protein Tyrosine Phosphatases - chemistry, Protein Tyrosine Phosphatases - metabolism, src Homology Domains, Structure-Activity Relationship, Sulfamic acid, Sulfonic Acids - chemical synthesis, Sulfonic Acids - chemistry, Sulfonic Acids - pharmacology, Tetrahydroisoquinoline, Tetrahydroisoquinolines - chemistry