Analytical chemistry (Washington), 2009-09, Vol.81 (17), p.7501-7506
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Half-Life Mapping of Nitroxyl Radicals with Three-Dimensional Electron Paramagnetic Resonance Imaging at an Interval of 3.6 Seconds
- Ist Teil von
- Analytical chemistry (Washington), 2009-09, Vol.81 (17), p.7501-7506
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- This technical note reports a continuous-wave electron paramagnetic resonance (CW-EPR) imager that can visualize the distribution of free radicals with a half-life of subminutes in three-dimensional (3D) space. A total of 46 EPR spectra under magnetic field gradients, called projections, were obtained for image reconstruction at an interval of 3.6 s. A shortened data-acquisition time was achieved with the use of analog signals that drove field gradient coils in the imager. 3D mapping of the half-lives of nitroxyl radicals (4-hydroxyl-2,2,6,6-tetramethyl-piperidinyl-1-oxyl) was demonstrated in their reduction reaction with ascorbic acid. Inhomogeneous half-lives were clearly mapped pixel-by-pixel in a sample tube.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0003-2700eISSN: 1520-6882DOI: 10.1021/ac901169gTitel-ID: cdi_proquest_miscellaneous_67622846
- Format
- –
- Schlagworte
- Analytical chemistry, Ascorbic Acid - metabolism, Chemistry, Electron Spin Resonance Spectroscopy - economics, Electron Spin Resonance Spectroscopy - instrumentation, Electron Spin Resonance Spectroscopy - methods, Equipment Design, Exact sciences and technology, Free radicals, Half-Life, Imaging, Three-Dimensional - economics, Imaging, Three-Dimensional - instrumentation, Imaging, Three-Dimensional - methods, Magnetic fields, Nitrogen Oxides - analysis, Nitrogen Oxides - metabolism, Oxidation-Reduction, Sensitivity and Specificity, Spectrometric and optical methods, Three dimensional imaging, Time Factors