Details

Autor(en) / Beteiligte

• Lin, J.J.
• Chen, C.H.
• Yueh, K.C.
• Chang, C.Y.
• Lin, S.Z.

Titel

A CD14 monocyte receptor polymorphism and genetic susceptibility to Parkinson's disease for females

Ist Teil von

• Parkinsonism & related disorders, 2006, Vol.12 (1), p.9-13

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2006

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Recent studies suggest that inflammation may play an important role in the pathogenesis of Parkinson's disease (PD). Because the C(−260)→T polymorphism in the promoter of the CD14 monocyte receptor gene ( pCD14) could affect the predisposition to the inflammatory response, we conducted a case-control study to investigate a possible genetic susceptibility of the pCD14 polymorphism in patients with PD. This study included 200 sporadic PD patients and 200 controls, matched by sex and case-control pairs for age at onset in the case. All observed genotype frequencies were in Hardy-Weinberg equilibrium. Results revealed that the CD14-T allele of the pCD14 polymorphism in the female PD patients existed statistically significant difference from that of the female controls (OR=1.262, P=0.038), but not for male. Female individuals with homozygote CD14-TT genotype were significantly increased risk of PD by 1.28 time ( P=0.027). Furthermore, a logistic regression analysis confirmed that the homozygote CD14-TT genotype was an independent risk factor for PD (OR=1.576, P=0.030). In conclusion, results of this study indicate the pCD14 polymorphism to be a genetic risk factor for PD in females.