Details

Autor(en) / Beteiligte

• Arai, Masaaki
• Kondoh, Nobuo
• Imazeki, Nobuo
• Hada, Akiyuki
• Hatsuse, Kazuo
• Kimura, Fumihiro
• Matsubara, Osamu
• Mori, Kazutoshi
• Wakatsuki, Toru
• Yamamoto, Mikio

Titel

Transformation-associated gene regulation by ATF6alpha during hepatocarcinogenesis

Ist Teil von

• FEBS letters, 2006-01, Vol.580 (1), p.184-190

Ort / Verlag

England

Erscheinungsjahr

2006

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• We have previously reported that the endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor 6 alpha (ATF6alpha) is implicated in the pathogenesis of hepatocellular carcinomas (HCCs). In order to further identify genes that are regulated by ATF6alpha, the global gene expression profiles of the ATF6alpha-transfected and untransfected HCC cell line, HLF, were analyzed. These results were then compared with the differential gene expression patterns of poorly differentiated HCC and control non-tumorous liver tissue. Our findings demonstrate that at least 18 genes are specifically upregulated by ATF6alpha, while another UPR mediator, XBP1 or ER-stress inducer, thapsigargin could partially stimulate or even repress some of them in HCC cells. Moreover, six of these identified genes contain potential ER stress-responsive elements and/or unfolded protein response elements in their 5' regulatory regions.