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A double-blind sham controlled study of right prefrontal repetitive transcranial magnetic stimulation (rTMS): Therapeutic and cognitive effect in medication free unipolar depression during 4 weeks
Ist Teil von
Progress in neuro-psychopharmacology & biological psychiatry, 2006, Vol.30 (1), p.126-130
Ort / Verlag
Amsterdam: Elsevier Inc
Erscheinungsjahr
2006
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Transcranial magnetic stimulation (TMS) has become a therapeutic tool in psychiatric diseases.
The objective was to evaluate the efficacy of TMS in unipolar depression: the percentage of responders (>
50% HDRS reduction) and remission (HDRS score ≤
8, after four weeks of active TMS treatment in depressed patients free of any antidepressive agent versus placebo-TMS.
27 patients were randomized in two groups: rTMS (
N
=
11) versus sham TMS (
N
=
16). Statistical differences were detected between sham and TMS treated groups on remission (0
/
16 versus 4
/
11
p
=
0.032, 1
/
16 versus 6
/
11 0.028 and 1
/
16 versus 7
/
11
p
=
0.011 at day 14, day 21 and day 28, respectively) and on response (2
/
16 versus 5
/
11 at day 14 (NS), 2
/
16 versus 7
/
11
p
=
0.0115 at day 21 and 1
/
16 versus 7
/
11 (
p
=
0.025) day 28, respectively, using the exact Fisher test). Significant differences were observed between day 1 versus day 8 (
p
<
0.01), day 15, day 21 and day 28 (
p
<
0.001) in TMS group and only versus day 21 (
p
<
0.01) and day 28 (
p
<
0.05) for the sham group. ANOVA comparison between TMS and sham groups was significant at day 14 and day 28 (
p
<
0.05).
The few number of patients.
Our study has shown an efficacy of right rTMS in free medication unipolar depression over a month. Nevertheless, number of patients included is limited and multicentric studies will be necessary to specify the antidepressive action of TMS.