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Dengue virus infection of human microvascular endothelial cells from different vascular beds promotes both common and specific functional changes
Journal of medical virology, 2006-02, Vol.78 (2), p.229-242
Peyrefitte, Christophe N.
Pastorino, Boris
Grau, Georges E.
Lou, J.
Tolou, Hugues
Couissinier-Paris, Patricia
2006
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Peyrefitte, Christophe N.
Pastorino, Boris
Grau, Georges E.
Lou, J.
Tolou, Hugues
Couissinier-Paris, Patricia
Titel
Dengue virus infection of human microvascular endothelial cells from different vascular beds promotes both common and specific functional changes
Ist Teil von
Journal of medical virology, 2006-02, Vol.78 (2), p.229-242
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2006
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Dengue shock syndrome (DSS), the major life threatening outcome of severe dengue disease, which occurs in some patients in the course of dengue infection, is the consequence of plasma leakage in the microvascular territories. Data from clinical and in vitro studies suggest that an inadequate immunological response is partly responsible for the pathophysiology of DSS, but few is known concerning the consequences of direct infection of endothelial cells by dengue virus per se. In this study, an attempt was made to study the response of two microvascular human cell lines originating, respectively, from liver and dermis to infection by a dengue type 2 virus, by analyzing the virus‐induced modulation of functional markers. It is shown that the two microvascular cell lines exhibit both common and specific behaviors upon infection. In particular, LSEC and HMEC‐1 replicate efficiently the low‐passage virus and respond to infection by over‐producing inflammatory mediators involved in the cross talk with circulating immune cells. However, direct infection modulates differently the cell surface expression of molecules critically involved in the interactions between endothelial and inflammatory cells. ICAM‐1 and HLA‐I are up regulated as a consequence of infection in LSEC whereas direct infection results in downregulation of ICAM‐1 in HMEC‐1. The present results show that infection of human microvascular cells by unadapted dengue virus results in both common and specific activation patterns depending likely on the tissue origin of the cells, thus suggesting that endothelia from different territories may contribute differently to the pathophysiological events in the course of dengue infection. J. Med. Virol. 78:229–242, 2006. © 2005 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0146-6615
eISSN: 1096-9071
DOI: 10.1002/jmv.20532
Titel-ID: cdi_proquest_miscellaneous_67596545
Format
–
Schlagworte
activation
,
Arboviroses
,
Biological and medical sciences
,
Dengue - metabolism
,
Dengue - physiopathology
,
Dengue - virology
,
Dengue fevers
,
Dengue virus
,
Dengue Virus - physiology
,
Endothelial Cells - metabolism
,
Endothelial Cells - virology
,
endothelium
,
flavivirus
,
Fundamental and applied biological sciences. Psychology
,
Histocompatibility Antigens Class I - metabolism
,
Human viral diseases
,
Humans
,
Infectious diseases
,
Intercellular Adhesion Molecule-1 - metabolism
,
Liver - blood supply
,
Medical sciences
,
Microbiology
,
Microcirculation
,
Miscellaneous
,
plasma leakage
,
Skin - blood supply
,
Species Specificity
,
Tropical viral diseases
,
Up-Regulation
,
Viral diseases
,
Virology
,
virus
,
Virus Replication
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