Details

Autor(en) / Beteiligte

• Hofma, Sjoerd H.
• van der Giessen, Wim J.
• van Dalen, Bas M.
• Lemos, Pedro A.
• McFadden, Eugene P.
• Sianos, Georgios
• Ligthart, Jurgen M.R.
• van Essen, Dirk
• de Feyter, Pim J.
• Serruys, Patrick W.

Titel

Indication of long-term endothelial dysfunction after sirolimus-eluting stent implantation

Ist Teil von

• European heart journal, 2006-01, Vol.27 (2), p.166-170

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2006

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Aims Endothelial dysfunction has been related both to progression of atherosclerotic disease and to future cardiovascular events. We assessed local epicardial endothelial function 6 months after sirolimus-eluting stent (SES) or bare metal stent (BS) implantation. Methods and results In 12 patients (seven SES, five BS), endothelium-dependent vasomotion of a coronary segment 15 mm in length, starting 2 mm distal to the stent, was assessed with quantitative coronary angiography immediately after the procedure and at 6 months follow-up, after intracoronary infusion of acetylcholine. Intravascular ultrasound (IVUS) was performed and coronary flow reserve (CFR) assessed in all patients. At follow-up significant vasoconstriction was seen in SES (median 32% diameter reduction from baseline) but not in BS (median 2% reduction) patients after acetylcholine infusion (P=0.03 for SES vs. BS); endothelium-independent vasodilatation to nitrates did not differ significantly between groups (20% SES, 5% BS, P=0.14). IVUS revealed no late unhealed dissections and CFR was comparable between groups (SES 3.1 vs. BS 3.2, n.s.). Conclusion SES implantation may have an adverse effect on local endothelium-dependent vasomotor responses compared with BS implantation at 6 months. Long-term clinical consequences of this observation are still unknown.