Details

Autor(en) / Beteiligte

• Liu, Wei‐Jun
• Lv, Bing‐Da
• Gong, Liu‐Zhu

Titel

An Asymmetric Catalytic Darzens Reaction between Diazoacetamides and Aldehydes Generates cis‐Glycidic Amides with High Enantiomeric Purity

Ist Teil von

• Angewandte Chemie International Edition, 2009-01, Vol.48 (35), p.6503-6506

Ort / Verlag

Weinheim: WILEY‐VCH Verlag

Erscheinungsjahr

2009

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Titanium strength: The title reaction was catalyzed by a chiral titanium complex formed in situ from commercially available Ti(OiPr)4 and (R)‐binol, and gave cis‐glycidic amides with excellent enantiomeric purity (see scheme). This new method has been applied to the preparation of chiral building blocks used for the synthesis of the side chain of taxol and (−)‐bestatin.