Details

Autor(en) / Beteiligte

• de Boer, Maaike
• van Deurzen, Carolien H.M
• van Dijck, Jos A.A.M
• Borm, George F
• van Diest, Paul J
• Adang, Eddy M.M
• Nortier, Johan W.R
• Rutgers, Emiel J.T
• Seynaeve, Caroline
• Menke-Pluymers, Marian B.E
• Bult, Peter
• Tjan-Heijnen, Vivianne C.G

Titel

Micrometastases or Isolated Tumor Cells and the Outcome of Breast Cancer

Ist Teil von

• The New England journal of medicine, 2009-08, Vol.361 (7), p.653-663

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2009

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• This study involving women with early-stage breast cancer showed an association between the presence of isolated tumor cells or micrometastases in sentinel or axillary lymph nodes and the 5-year rate of disease-free survival. Women with such findings in these lymph nodes who received systemic adjuvant therapy had an improved outcome. This study involving women with early-stage breast cancer showed an association between the presence of isolated tumor cells or micrometastases in sentinel or axillary lymph nodes and the 5-year rate of disease-free survival. Women with such findings in these lymph nodes who received systemic adjuvant therapy had an improved outcome. The status of the axillary lymph nodes is the most important prognostic factor in breast cancer. 1 These nodes can be sampled by axillary lymph-node dissection or sentinel-node biopsy with or without subsequent axillary lymph-node dissection (these additional lymph nodes are denoted as nonsentinel nodes). Detailed examination of the sentinel node by means of serial sectioning with optional immunohistochemical staining permits the detection of small metastases or isolated tumor cells. 2 – 4 Isolated tumor cells (staged as pN0[i+], with deposits ≤0.2 mm) and micrometastases (staged as pN1mi, with deposits >0.2 to ≤2.0 mm) have been separate categories in the American Joint Committee . . .