Details

Autor(en) / Beteiligte

• Canté-Barrett, Kirsten
• Crabtree, Gerald R
• Gallo, Elena M

Titel

Lymphocyte calcium signaling from membrane to nucleus

Ist Teil von

• Nature immunology, 2006-01, Vol.7 (1), p.25-32

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• Ca(2+) signals control a variety of lymphocyte responses, ranging from short-term cytoskeletal modifications to long-term changes in gene expression. The identification of molecules and channels that modulate Ca(2+) entry into T and B lymphocytes has both provided details of the molecular events leading to immune responses and raised controversy. Here we review studies of the pathways that allow Ca(2+) entry, the function of Ca(2+) in the regulation of cell polarity and motility and the principles by which Ca(2+)-dependent transcription regulates lymphocyte function.