Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2274-2277
2005
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Details
- Autor(en) / Beteiligte
- Titel
- Discovery of Bicycloalkyl Urea Melanin Concentrating Hormone Receptor Antagonists: Orally Efficacious Antiobesity Therapeutics
- Ist Teil von
- Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2274-2277
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Melanin concentrating hormone (MCH) is involved in regulation of food intake and energy homeostasis. Antagonists of the MCH receptor are expected to affect food intake and weight gain, making MCH-R1 an attractive target for obesity treatment. Herein, we report the discovery of a novel, orally active series of MCH-R1 antagonists that exhibit in vivo efficacy in rodent obesity models.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-2623eISSN: 1520-4804DOI: 10.1021/jm049035qTitel-ID: cdi_proquest_miscellaneous_67568533
- Format
- –
- Schlagworte
- Administration, Oral, Animals, Anti-Obesity Agents - chemical synthesis, Anti-Obesity Agents - chemistry, Anti-Obesity Agents - pharmacology, Biological and medical sciences, Biological Availability, Brain - metabolism, Bridged Bicyclo Compounds - chemical synthesis, Bridged Bicyclo Compounds - chemistry, Bridged Bicyclo Compounds - pharmacology, Cycloheptanes - chemical synthesis, Cycloheptanes - chemistry, Cycloheptanes - pharmacology, Cyclohexanes - chemical synthesis, Cyclohexanes - chemistry, Cyclohexanes - pharmacology, Eating - drug effects, General and cellular metabolism. Vitamins, Medical sciences, Mice, Obesity - drug therapy, Pharmacology. Drug treatments, Rats, Receptors, Pituitary Hormone - antagonists & inhibitors, Receptors, Somatostatin - antagonists & inhibitors, Urea - analogs & derivatives, Urea - chemical synthesis, Urea - chemistry, Urea - pharmacology