Details

Autor(en) / Beteiligte

• Mas Marques, Andreas
• Mueller, Tobias
• Welke, Justus
• Taube, Stefan
• Sarrazin, Christoph
• Wiese, Manfred
• Halangk, Juliane
• Witt, Heiko
• Ahlenstiel, Golo
• Spengler, Ulrich
• Goebel, Uwe
• Schott, Eckart
• Weich, Viola
• Schlosser, Beate
• Wasmuth, Hermann E.
• Lammert, Frank
• Berg, Thomas
• Schreier, Eckart

Titel

Low-density lipoprotein receptor variants are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection

Ist Teil von

• Infection, genetics and evolution, 2009-09, Vol.9 (5), p.847-852

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2009

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Low-density lipoprotein receptor (LDLR) is involved in the entry of hepatitis C virus (HCV) in host cells. We investigated whether three single-nucleotide alterations within LDLR might be associated with the course of hepatitis C infection and response to antiviral therapy. We enrolled 651 individuals with chronic HCV infection who had received interferon-based combination therapy, 174 individuals with self-limited HCV infection, and 516 healthy controls. LDLR c.1171G > A, c.1413G > A, and c.*52G > A genotyping was performed by real-time PCR-based assays. HCV genotype 1-infected individuals who were homozygous for 3′UTR c.*52G were at increased risk for virologic non-response to antiviral therapy compared to virologic responders (66.3% vs. 51.0%, p = 0.001). Furthermore, compared to healthy controls, self-limited HCV genotype 1 infection was significantly associated with c.1171A (15.1% vs. 6.6%, p = 0.006) and negatively associated with c.1413G > A heterozygosity (33.0% vs. 46.1%, p = 0.023). The data indicate that LDLR alterations are correlated with response to interferon-based combination therapy and with self-limitation of HCV 1 infection.