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Light promotes regeneration and functional recovery and alters the immune response after spinal cord injury
Lasers in surgery and medicine, 2005-03, Vol.36 (3), p.171-185
Byrnes, Kimberly R.
Waynant, Ronald W.
Ilev, Ilko K.
Wu, Xingjia
Barna, Lauren
Smith, Kimberly
Heckert, Reed
Gerst, Heather
Anders, Juanita J.
2005
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Byrnes, Kimberly R.
Waynant, Ronald W.
Ilev, Ilko K.
Wu, Xingjia
Barna, Lauren
Smith, Kimberly
Heckert, Reed
Gerst, Heather
Anders, Juanita J.
Titel
Light promotes regeneration and functional recovery and alters the immune response after spinal cord injury
Ist Teil von
Lasers in surgery and medicine, 2005-03, Vol.36 (3), p.171-185
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2005
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Background and Objectives Photobiomodulation (PBM) has been proposed as a potential therapy for spinal cord injury (SCI). We aimed to demonstrate that 810 nm light can penetrate deep into the body and promote neuronal regeneration and functional recovery. Study Design/Materials and Methods Adult rats underwent a T9 dorsal hemisection, followed by treatment with an 810 nm, 150 mW diode laser (dosage = 1,589 J/cm2). Axonal regeneration and functional recovery were assessed using single and double label tract tracing and various locomotor tasks. The immune response within the spinal cord was also assessed. Results PBM, with 6% power penetration to the spinal cord depth, significantly increased axonal number and distance of regrowth (P < 0.001). PBM also returned aspects of function to baseline levels and significantly suppressed immune cell activation and cytokine/chemokine expression. Conclusion Our results demonstrate that light, delivered transcutaneously, improves recovery after injury and suggests that light will be a useful treatment for human SCI. © 2005 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0196-8092
eISSN: 1096-9101
DOI: 10.1002/lsm.20143
Titel-ID: cdi_proquest_miscellaneous_67531654
Format
–
Schlagworte
Animals
,
astrocytes
,
Axons - physiology
,
corticospinal tract
,
Cytokines - metabolism
,
Ectodysplasins
,
Female
,
footprint analysis
,
Glial Fibrillary Acidic Protein - metabolism
,
Immunohistochemistry
,
Leukocyte Common Antigens - metabolism
,
Locomotion - radiation effects
,
low power laser irradiation
,
Low-Level Light Therapy
,
macrophage
,
Macrophages - metabolism
,
Membrane Proteins - metabolism
,
microglia
,
Nerve Regeneration - physiology
,
Neuroglia - metabolism
,
Nitric Oxide Synthase - metabolism
,
photobiomodulation
,
Radiotherapy Dosage
,
rat
,
Rats
,
Rats, Sprague-Dawley
,
Recovery of Function - physiology
,
retrograde and anterograde tract tracing
,
Spectrophotometry
,
Spinal Cord Injuries - physiopathology
,
Spinal Cord Injuries - radiotherapy
,
T-Lymphocytes - metabolism
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