Details

Autor(en) / Beteiligte

• Corthay, Alexandre
• Skovseth, Dag K.
• Lundin, Katrin U.
• Røsjø, Egil
• Omholt, Hilde
• Hofgaard, Peter O.
• Haraldsen, Guttorm
• Bogen, Bjarne

Titel

Primary Antitumor Immune Response Mediated by CD4 + T Cells

Ist Teil von

• Immunity (Cambridge, Mass.), 2005-03, Vol.22 (3), p.371-383

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• Gene-targeted mice have recently revealed a role for lymphocytes and interferon-γ (IFNγ) in conferring protection against cancer, but the mechanisms remain unclear. Here, we have characterized a successful primary antitumor immune response initiated by naive CD4 + T cells. Major histocompatibility complex class II (MHC-II)-negative myeloma cells injected subcutaneously into syngeneic mice were surrounded within 3 days by macrophages that captured tumor antigens. Within 6 days, naive myeloma-specific CD4 + T cells became activated in draining lymph nodes and subsequently migrated to the incipient tumor site. Upon recognition of tumor-derived antigenic peptides presented on MHC-II by macrophages, the myeloma-specific CD4 + T cells were reactivated and started to secrete cytokines. T cell-derived IFNγ activated macrophages in close proximity to the tumor cells. Tumor cell growth was completely inhibited by such locally activated macrophages. These data indicate a mechanism for immunosurveillance of MHC-II-negative cancer cells by tumor-specific CD4 + T cells through collaboration with macrophages.