Details

Autor(en) / Beteiligte

• Jarvis, Gary A.
• Janoff, Edward N.
• Cheng, Hui
• Devita, Deborah
• Fasching, Claudine
• McCulloch, Charles E.
• Murphy, Edward L.

Titel

Human T Lymphotropic Virus Type II Infection and Humoral Responses to Pneumococcal Polysaccharide and Tetanus Toxoid Vaccines

Ist Teil von

• The Journal of infectious diseases, 2005-04, Vol.191 (8), p.1239-1244

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2005

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Infection with human T lymphotropic virus type II (HTLV-II) has been linked to an increased incidence of bacterial pneumonia. To determine whether HTLV-II infection is associated with impaired humoral immune responses, we immunized a cohort of HTLV-II–infected subjects and matched uninfected control subjects with 23-valent pneumococcal polysaccharide and tetanus toxoid vaccines. The pneumococcal polysaccharide vaccine elicited comparable and significant increases in concentrations of IgG against all 5 serotypes tested at 1 and 6 months after immunization in both groups. The avidity and opsonophagocytic functions of the anticapsular IgG were similar. The concentrations of tetanus toxoid–specific IgG also increased comparably and significantly over time in both groups. Thus, HTLV-II–infected persons develop robust humoral responses to potentially protective polysaccharide and protein vaccines