Details

Autor(en) / Beteiligte

• Porthan, Kimmo, MD
• Viitasalo, Matti, MD, PhD
• Jula, Antti, MD, PhD
• Reunanen, Antti, MD, PhD
• Rapola, Janne, MD, PhD
• Väänänen, Heikki, MSc
• Nieminen, Markku S., MD, PhD
• Toivonen, Lauri, MD, PhD, FHRS
• Salomaa, Veikko, MD, PhD
• Oikarinen, Lasse, MD, PhD

Titel

Predictive value of electrocardiographic QT interval and T-wave morphology parameters for all-cause and cardiovascular mortality in a general population sample

Ist Teil von

• Heart rhythm, 2009-08, Vol.6 (8), p.1202-1208.e1

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Background The predictive value of ECG QT interval for mortality in the general population has been weak. Only a few population studies on the predictive value of ECG T-wave morphology parameters for mortality have been reported. Objective The purpose of this study was to examine the predictive value of ECG QT interval and T-wave morphology parameters for all-cause and cardiovascular mortality in the general population. Methods The prognostic values of ECG QT interval and four T-wave morphology parameters (principal component analysis ratio, T-wave morphology dispersion, total cosine R-to-T, T-wave residuum) were assessed in 5,917 adults (45% men; age 52 ± 14 years) participating in the Finnish population-based Health 2000 Study. Results After a mean follow-up of 5.9 ± 0.8 years, 335 deaths had occurred, including 131 cardiovascular deaths. QT interval and, with a few exceptions, all T-wave morphology parameters were significant univariate mortality predictors. In men, in Cox multivariate analyses, principal component analysis ratio and T-wave morphology dispersion remained as independent predictors of all-cause and cardiovascular mortality, with the above-median T-wave morphology dispersion group showing the highest risk of cardiovascular death (hazard ratio [HR] 4.4, 95% confidence interval [CI] 2.1−9.4). In women, independent mortality predictors were total cosine R-to-T (cardiovascular mortality) and T-wave residuum (all-cause and cardiovascular mortality), with the above-median T-wave residuum group showing the highest risk of cardiovascular death (HR 2.2, 95% CI 1.1−4.2). Conclusion In the general population, T-wave morphology parameters, but not heart rate-corrected QT interval, provide independent prognostic information on mortality. The prognostic value of T-wave morphology parameters is specifically related to cardiovascular mortality and seems to be gender specific.