European journal of medicinal chemistry, 2009-09, Vol.44 (9), p.3805-3809
2009
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Details
- Autor(en) / Beteiligte
- Titel
- A facile one-pot green synthesis and antibacterial activity of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes
- Ist Teil von
- European journal of medicinal chemistry, 2009-09, Vol.44 (9), p.3805-3809
- Ort / Verlag
- Kidlington: Elsevier
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A facile one-pot expeditious synthesis of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes has been described under solvent-free conditions using magnesium oxide as a catalyst in very good yields. The reaction catalyst, magnesium oxide was reused and recycled without any loss of activity and product yield. All the synthesized compounds were screened for in vitro antibacterial activity, and compounds 3a, 3b, 3f, 4b, 4c, 4d, 4e and 4g showed complete inhibition of bacterial growth at 128 microg/mL or less and the rest of the compounds exhibited incomplete inhibition.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0223-5234eISSN: 1768-3254DOI: 10.1016/j.ejmech.2009.04.017Titel-ID: cdi_proquest_miscellaneous_67499824
- Format
- –
- Schlagworte
- Anti-Bacterial Agents - chemical synthesis, Anti-Bacterial Agents - chemistry, Anti-Bacterial Agents - pharmacology, Antibacterial agents, Antibiotics. Antiinfectious agents. Antiparasitic agents, Benzopyrans - chemical synthesis, Benzopyrans - chemistry, Benzopyrans - pharmacology, Biological and medical sciences, Catalysis, Escherichia coli - drug effects, Medical sciences, Microbial Sensitivity Tests, Pharmacology. Drug treatments, Pseudomonas aeruginosa - drug effects, Pseudomonas putida - drug effects, Pyrans - chemical synthesis, Pyrans - chemistry, Pyrans - pharmacology, Staphylococcus aureus - drug effects, Structure-Activity Relationship