Details

Autor(en) / Beteiligte

• Thomson, R.L.
• Buckley, J.D.
• Moran, L.J.
• Noakes, M.
• Clifton, P.M.
• Norman, R.J.
• Brinkworth, G.D.

Titel

The effect of weight loss on anti-Müllerian hormone levels in overweight and obese women with polycystic ovary syndrome and reproductive impairment

Ist Teil von

• Human reproduction (Oxford), 2009-08, Vol.24 (8), p.1976-1981

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2009

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• BACKGROUND Anti-Müllerian hormone (AMH) has been proposed as a clinical predictor of improvements in reproductive function following weight loss in overweight and obese women with polycystic ovary syndrome (PCOS). This study aimed to assess whether baseline and/or change in AMH levels with weight loss predict improvements in reproductive function in overweight and obese women with PCOS. METHODS Fifty-two overweight and obese women with PCOS and reproductive impairment (age 29.8 ± 0.8 years, BMI 36.5 ± 0.7 kg/m2) followed a 20-week weight loss programme. AMH, weight, menstrual cyclicity and ovulatory function were assessed at baseline and post-intervention. RESULTS Participants who responded with improvements in reproductive function (n = 26) had lower baseline AMH levels (23.5 ± 3.7 versus 32.5 ± 2.9 pmol/l; P = 0.03) and experienced greater weight loss (−11.7 ± 1.2 versus −6.4 ± 0.9 kg; P = 0.001) compared with those who did not respond (n = 26). Logistic regression analysis showed that weight loss and baseline AMH were independently related to improvements in reproductive function (P = 0.002 and P = 0.013, respectively). AMH levels did not change with weight loss in both responders and non-responders. CONCLUSIONS In overweight and obese women with PCOS and reproductive dysfunction, a 20-week weight loss intervention resulted in improvements in reproductive function but no change in AMH levels. Clinical Trials Registration Number: ACTRN12606000198527