Journal of neuroimmunology, 2009-07, Vol.212 (1), p.125-131
2009
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- Autor(en) / Beteiligte
- Titel
- Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10 , NOD1-2 , DDX58 , and IFIH1
- Ist Teil von
- Journal of neuroimmunology, 2009-07, Vol.212 (1), p.125-131
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Genetic factors are critical in multiple sclerosis (MS), and it is conceivable that the pattern recognition receptors of the innate immune system are of pathogenic importance. We therefore developed two novel assays capable of analyzing 42 single-nucleotide polymorphisms in the human genes encoding TLR1-10, NOD1-2, DDX58, and IFIH1. Using these assays, we genotyped 963 MS patients and 960 controls, and analyzed for possible associations to MS diagnosis, clinical course, severity, and age at onset. Our results support previous findings of associations between the IFIH1 -locus and MS ( IFIH1 -rs3747517 and IFIH1 -rs1990760 trend test: P = 0.002 and P = 0.014, respectively).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0165-5728eISSN: 1872-8421DOI: 10.1016/j.jneuroim.2009.04.008Titel-ID: cdi_proquest_miscellaneous_67482622
- Format
- –
- Schlagworte
- Adolescent, Adult, Aged, Aged, 80 and over, Allergy and Immunology, Animals, DEAD Box Protein 58, DEAD-box RNA Helicases - genetics, Encephalomyelitis, Autoimmune, Experimental - immunology, Female, Genome-Wide Association Study, Genotype, Humans, Immunity, Innate, Interferon-Induced Helicase, IFIH1, Male, Mice, Middle Aged, Multiple sclerosis, Multiple Sclerosis - diagnosis, Multiple Sclerosis - genetics, Multiple Sclerosis - immunology, Multiple sclerosis severity score, Neurology, Nod1 Signaling Adaptor Protein - genetics, Nod2 Signaling Adaptor Protein - genetics, Pattern recognition receptors, Polymorphism, Single Nucleotide, Receptors, Immunologic, Sex Characteristics, Single-nucleotide polymorphism, Toll-like receptors, Toll-Like Receptors - genetics