Details

Autor(en) / Beteiligte

• Zerr, Danielle M
• Meier, Amalia S
• Selke, Stacy S
• Frenkel, Lisa M
• Huang, Meei-Li
• Wald, Anna
• Rhoads, Margaret P
• Nguy, Long
• Bornemann, Rena
• Morrow, Rhoda Ashley
• Corey, Lawrence

Titel

A Population-Based Study of Primary Human Herpesvirus 6 Infection

Ist Teil von

• The New England journal of medicine, 2005-02, Vol.352 (8), p.768-776

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• In this study of serial saliva specimens from 277 children, 40 percent were infected with human herpesvirus 6 (HHV-6) by 12 months of age and 77 percent were infected by 2 years of age. Nearly all primary infections were symptomatic, with almost 40 percent leading to clinic visits for symptoms such as fever, fussiness, and diarrhea. In this study of serial saliva specimens from 277 children, 40 percent were infected with human herpesvirus 6 by 12 months of age and 77 percent were infected by 2 years of age. Human herpesvirus 6 (HHV-6) infects over 90 percent of people within the first two years of life. 1 Studies of febrile children in the emergency department indicate that primary HHV-6 infection accounts for a large proportion of visits and febrile seizures. 2 Despite the interest in HHV-6 as an important pathogen, 3 – 5 no prospective, population-based study has evaluated the acquisition of HHV-6 outside the acute care setting. Thus, the full spectrum of illness and virologic aspects of primary HHV-6 infection remain unknown. We developed a noninvasive method of testing serially collected saliva specimens for HHV-6 6 and used it prospectively in children from . . .