Trends in endocrinology and metabolism, 2009-07, Vol.20 (5), p.223-229
2009
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- Autor(en) / Beteiligte
- Titel
- New mechanisms for PRLr action in breast cancer
- Ist Teil von
- Trends in endocrinology and metabolism, 2009-07, Vol.20 (5), p.223-229
- Ort / Verlag
- Cambridge, MA: Elsevier Ltd
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Prolactin (PRL) is a pleiotrophic hormone that contributes to the growth of normal and malignant breast tissues. PRL signals through its receptor (PRLr), a transmembrane receptor that belongs to the cytokine receptor family. The mechanism of how the PRL:PRLr interaction triggers activation of signaling networks remains enigmatic. This review examines the effect of ligand binding on PRLr and the processes that initiate receptor-associated signaling. Evidence for PRLr predimerization in the absence of ligand and the actions of the prolyl isomerase cyclophilin A in ligand-induced activation of PRLr-associated Jak2 kinase are discussed. These studies reveal that ligand-induced conformational change of the PRLr complex is necessary for its function and open avenues for therapies to inhibit PRLr action in breast cancer.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1043-2760eISSN: 1879-3061DOI: 10.1016/j.tem.2009.03.001Titel-ID: cdi_proquest_miscellaneous_67437370
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Breast Neoplasms - metabolism, Cyclophilin A - pharmacology, Endocrinology & Metabolism, Female, Fundamental and applied biological sciences. Psychology, Gynecology. Andrology. Obstetrics, Humans, Mammary gland diseases, Medical sciences, Models, Biological, Prolactin - metabolism, Prolactin - physiology, Protein Multimerization, Receptors, Prolactin - metabolism, Signal Transduction - drug effects, Tumors, Vertebrates: endocrinology