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Effect of Citrus paradisi extract and juice on arterial pressure both in vitro and in vivo
Phytotherapy research, 2009-07, Vol.23 (7), p.948-954
Díaz-Juárez, J.A
Tenorio-López, F.A
Zarco-Olvera, G
Valle-Mondragón, L. del
Torres-Narváez, J.C
Pastelín-Hernández, G
2009
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Díaz-Juárez, J.A
Tenorio-López, F.A
Zarco-Olvera, G
Valle-Mondragón, L. del
Torres-Narváez, J.C
Pastelín-Hernández, G
Titel
Effect of Citrus paradisi extract and juice on arterial pressure both in vitro and in vivo
Ist Teil von
Phytotherapy research, 2009-07, Vol.23 (7), p.948-954
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2009
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Citrus paradisi (grapefruit) consumption is considered as beneficial and it is popularly used for the treatment of a vast array of diseases, including hypertension. In the present study, the coronary vasodilator and hypotensive effects of Citrus paradisi peel extract were assessed in the Langendorff isolated and perfused heart model and in the heart and lung dog preparation. In both models, Citrus paradisi peel extract decreased coronary vascular resistance and mean arterial pressure when compared with control values (60 ± 15 x 10⁷ dyn s cm⁻⁵ vs 100 ± 10 x 10⁷ dyn s cm⁻⁵ and 90 mmHg vs 130 ± 15 mmHg, respectively). These decreases in coronary vascular resistance and mean arterial pressure were blocked when isolated and perfused hearts and mongrel dogs were pre-treated with L-NAME. In humans, Citrus paradisi juice decreased diastolic arterial pressure and systolic arterial pressure both in normotensive and hypertensive subjects. Citrus paradisi juice produced a greater decrease in mean arterial pressure when compared with Citrus sinensis juice, cow milk and a vitamin C-supplemented beverage. However, more detailed studies are required to isolate, purify and evaluate the chemical compounds responsible for this pharmacological effect and to clarify its possible role for treating hypertension. Copyright © 2009 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0951-418X
eISSN: 1099-1573
DOI: 10.1002/ptr.2680
Titel-ID: cdi_proquest_miscellaneous_67419536
Format
–
Schlagworte
Animals
,
Antihypertensive Agents - pharmacology
,
Biological and medical sciences
,
Blood Pressure - drug effects
,
Citrus paradisi
,
Citrus paradisi - chemistry
,
coronary vasodilator effect
,
Dogs
,
Female
,
flavonoids
,
General pharmacology
,
Heart - drug effects
,
human subjects
,
Humans
,
Hypertension - drug therapy
,
Lung - drug effects
,
Male
,
mean arterial pressure
,
Medical sciences
,
NG-Nitroarginine Methyl Ester - pharmacology
,
nitric oxide
,
Pharmacognosy. Homeopathy. Health food
,
Pharmacology. Drug treatments
,
Plant Extracts - pharmacology
,
Rats
,
Rats, Wistar
,
Vascular Resistance - drug effects
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