Details

Autor(en) / Beteiligte

• Bahlo, Melanie
• Booth, David R
• Broadley, Simon A
• Brown, Matthew A
• Foote, Simon J
• Griffiths, Lyn R
• Kilpatrick, Trevor J
• Lechner-Scott, Jeanette
• Moscato, Pablo
• Perreau, Victoria M
• Rubio, Justin P
• Scott, Rodney J
• Stankovich, Jim
• Stewart, Graeme J
• Taylor, Bruce V
• Wiley, James
• Clarke, Glynnis
• Cox, Mathew B
• Csurhes, Peter A
• Danoy, Patrick
• Drysdale, Karen
• Field, Judith
• Greer, Judith M
• Guru, Preethi
• Hadler, Johanna
• McMorran, Brendan J
• Jensen, Cathy J
• Johnson, Laura J
• McCallum, Ruth
• Merriman, Marilyn
• Merriman, Tony
• Pryce, Karen
• Tajouri, Lotfi
• Wilkins, Ella J
• Browning, Brian L
• Browning, Sharon R
• Perera, Devindri
• Broadley, Simon
• Butzkueven, Helmut
• Carroll, William M
• Chapman, Caron
• Kermode, Allan G
• Marriott, Mark
• Mason, Deborah
• Heard, Robert N
• Pender, Michael P
• Slee, Mark
• Tubridy, Niall
• Willoughby, Ernest

Titel

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

Ist Teil von

• Nature genetics, 2009-07, Vol.41 (7), p.824-828

Ort / Verlag

New York: Nature Publishing Group US

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an independent set of 2,256 cases and 2,310 controls, for a total of 3,874 cases and 5,723 controls. We identified risk-associated SNPs on chromosome 12q13-14 (rs703842, P = 5.4 × 10−11; rs10876994, P = 2.7 × 10−10; rs12368653, P = 1.0 × 10−7) and upstream of CD40 on chromosome 20q13 (rs6074022, P = 1.3 × 10−7; rs1569723, P = 2.9 × 10−7). Both loci are also associated with other autoimmune diseases. We also replicated several known MS associations (HLA-DR15, P = 7.0 × 10−184; CD58, P = 9.6 × 10−8; EVI5-RPL5, P = 2.5 × 10−6; IL2RA, P = 7.4 × 10−6; CLEC16A, P = 1.1 × 10−4; IL7R, P = 1.3 × 10−3; TYK2, P = 3.5 × 10−3) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).