Details

Autor(en) / Beteiligte

• Steiger, H
• Joober, R
• Israel, M
• Young, S.N
• Ng Ying Kin, N.M.K
• Gauvin, L
• Bruce, K.R
• Joncas, J
• Torkaman-Zehi, A

Titel

5HTTLPR polymorphism, psychopathologic symptoms, and platelet [3H-] paroxetine binding in bulimic syndromes

Ist Teil von

• The International journal of eating disorders, 2005, Vol.37 (1), p.57-60

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2005

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Background: A short (s) allele in the promoter region of the 5-hydroxytryptamine (5-HT) transporter gene (5HTTLPR) has been associated with low transcription of the 5-HT transporter protein, and with clinical manifestations including impulsivity, affective disorder, and bulimia nervosa. Methods: We studied implications of the 5HTTLPR s allele for eating symptoms, psychopathologic traits, and platelet 3H- paroxetine binding in 59 women with bulimia spectrum syndromes. Results: Compared with those without it, carriers of the s allele of 5HTTLPR showed significantly more affective instability, behavioral impulsivity, interpersonal insecurity, comorbid borderline personality disorder (BPD), and lower density (B(max)) of paroxetine-binding sites. Conclusions: Our results suggest that proneness to impulsivity, affective dysregulation, and reduced central 5-HT reuptake may (in part) be codetermined by the 5HTTLPR polymorphism. However, given inconsistent 5HTTLPR expression in different populations, we speculate that we may be observing a phenotype (i.e., eating disorder)-dependent manifestation.