Details

Autor(en) / Beteiligte

• Van der Bij, Akke K.
• Kloosterboer, Nico
• Prins, Maria
• Boeser-Nunnink, Brigitte
• Geskus, Ronald B.
• Lange, Joep M. A.
• Coutinho, Roel A.
• Schuitemaker, Hanneke

Titel

GB Virus C Coinfection and HIV-1 Disease Progression: The Amsterdam Cohort Study

Ist Teil von

• The Journal of infectious diseases, 2005-03, Vol.191 (5), p.678-685

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2005

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• BackgroundThe effect that GB virus C (GBV-C) coinfection has on human immunodeficiency virus type 1 (HIV-1) disease progression is controversial and therefore was studied in 326 homosexual men from the prospective Amsterdam Cohort Studies who had an accurately estimated date of HIV-1 seroconversion and were followed up for a median period of 8 years MethodsA first plasma sample, obtained shortly after HIV-1 seroconversion, and a last plasma sample, obtained before 1996, were tested for GBV-C RNA and envelope protein–2 antibodies. The effect that GBV-C has on HIV-1 disease progression was studied by use of time-dependent Cox proportional-hazards models with adjustment for baseline variables and time-updated HIV-1 RNA and CD4+ cell count ResultsMen who lost GBV-C RNA between collection of the first sample and collection of the last sample had a nearly 3-fold-higher risk of HIV-1 disease progression than did men who had never had GBV-C RNA. This effect became much smaller after adjustment for time-updated CD4+ cell count ConclusionRather than a positive effect of GBV-C RNA presence, a negative effect of GBV-C RNA loss on HIV-1 disease progression was found, which disappeared after adjustment for time-updated CD4+ cell count. We therefore hypothesize that GBV-C RNA persistence depends on the presence of a sufficient number of CD4+ cells—and that the CD4+ cell decrease associated with HIV-1 disease progression is a cause, not a consequence, of GBV-C RNA loss